Seattle Genetics, Takeda begin Phase III Lymphoma trial

ADC drug expected to file in 1H11

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By: Tim Wright

Editor-in-Chief, Contract Pharma

Seattle Genetics, Takeda Pharmaceutical Co. and Millennium, Takeda’s oncology unit, have started a Phase III clinical trial of brentuximab vedotin (SGN-35) for post-transplant Hodgkin lymphoma patients. Brentuximab vedotin is an antibody-drug conjugate (ADC) targeted to CD30, which is expressed on malignant Hodgkin lymphoma cells. The trial, also known as AETHERA, will evaluate brentuximab vedotin versus placebo for the treatment of patients at high risk of residual Hodgkin lymphoma follow...

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